Benprost, bosentan, etc

Bosentan (bosmon tablet) for pphn

iNO is first line

Then milrinone

Then may add sildenafil with milrinone

Then comes bosentan (bosmon)

And benprost (beraprost) PGE2 agonist

And 

for keeping pda open, 

its PGE1 alprostadil 0.01 ug per kg per minute 

Then comes

Benprost (beraprost)

Milrinone

Term infant Preterm infant

Maintenance without loading dose

0.33 − 0.75 microgram/kg/minute 0.2 microgram/kg/minute

Or loading with 75ug/kg/minute over 1 hour

Susp Silagro 10mg/mL

1mg per kg per day divided 8 hrly

Sildenafil

Pulmonary hypertension Initially 0.25 to 0.5 mg/kg/dose every 4 to 8 hours, adjusting according to response.

Bosentan (tab bosmon 62.5 mg)

1 mg per kg per day divided 12 hourly

0.5-2 mg/kg/dose 12 hourly.

Suggested regimen: Commence at 0.5 mg/kg/dose 12 hourly. Increase incrementally in consultation with

neonatologist and/or cardiologist to a maximum of 2mg/kg/dose 12 hourly.

.....

Benprost (beraprost 20ug/tab)

1ug/kg/dose 6 hrly

TO KEEP DUCTUS ARTERIOSUS OPEN

It is used for pulmonary hypertension also.