Kaiser-Permanente Sepsis Risk Calculator

Probable neontal EOS risk based on maternal risk factor and infant's clinical presentation.
For 35 week or more gestation.
Probability of EOS per 1000 babies


EOS 2.0 Calculator 2024 Update by American Academy of Pediatrics

Sensitivity of the Kaiser EOS calculator is about 67% (by definition: ability to correctly identify true sepsis cases).
Specificity is about 92% (by definition: ability to correctly identify non-sepsis cases).
It reduces unnecessary antibiotics but may miss some sepsis cases.

The 2017 EOS calculator was based on data from 1993–2007 and classified maternal antibiotics per older CDC guidance.
The 2024 update (EOS 2.0) incorporates universal GBS screening, revised definitions of intrapartum antibiotic prophylaxis, and updated antibiotic classifications reflecting modern susceptibility and transplacental transfer.
In short, the 2024 model aligns with current obstetric practice, making risk estimates more accurate and clinically relevant. 

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