Guidelines for management of Hypernatremia in neonates

Amikacin causes hyponatremia (more often) and rarely hypernatremia (by impairing kidneys ability to concentrate urine and hence losing too much water, same mechanism for amphotericin)

8.4% Sodium bicarbonate (1mEq/mL)

Cefotaxime sodium (2 mEq Na per gram of drug)

Ceftriaxone sodium (3.5 mEq sodium per gram of drug), though ceftriaxone is not recommended routinely in neonatology.

Co-amoxiclav (Oral) contains amoxicillin as trihydrate salt, and clavulanic acid as potassium salt.

Co-amoxiclav (IV) contains amoxicillin as sodium salt 2.5mmol/gram and clavulanic acid as potassium salt 1mmol/gram.
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Pseudohypernatremia:
--low serum albumin (if indirect ion selective electrodes are used)

--hypotriglyeridemia

--sample of blood drawn from site proximal to infusion of sodium bicarbonate or any other sodium containing infusion.

Relating hypoalbuminemia: In real physiologic terms, for every 1g/dL fall of serum albumin, serum sodium falls by 2 mEq/L. This is because albumin is a negatively charged ion, and it hold positively charged sodium with it.