Prime the IV Tubing
Discard the first 20–30 mL of the insulin solution through the tubing. This step saturates the tubing with insulin, minimizing adsorption to the plastic and ensuring the patient receives the intended dose.
A 2012 in vitro study published in Diabetes Technology & Therapeutics evaluated insulin adsorption at various dwell times (0, 15, 30, and 60 minutes) and found no significant difference in insulin concentration delivered from the tubing across these intervals.
The key takeaway: a 20 mL flush of the insulin solution through the tubing is sufficient to saturate the plastic and minimize adsorption.
Other protocols encourage a dwell time of 30 minutes after flushing with 5 mL of insulin infusion, till the level of 3 way connector (if used).
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